Disclosure: TopShelf Mushrooms and Pilly Labs are operated by the same team. This page includes promotional links to Pilly Labs. Product comparisons are based on current labels, prices, policies, and cited research.
Side-by-Side, Same 1 mL Basis
Species listed: MaryRuth – Lion’s Mane, Reishi, Agaricus Blazei, Maitake, Shiitake, Turkey Tail (6). Pilly – Chaga, Reishi, Maitake, Shiitake, Turkey Tail, Cordyceps (6).
- Serving size: MaryRuth is 1 mL, up to three times daily. Pilly is 1 mL, once daily.
- Disclosed amount per serving: MaryRuth lists 1,200 mg of “Organic Proprietary Blend Extract” per 1 mL (all six species combined, not individually broken out). Pilly lists 150 mg “Proprietary Mushroom Immune Complex” covering five species (also not individually broken out), plus 50 mg of Cordyceps extract disclosed on its own line – 200 mg total per 1 mL.
- Servings per bottle: MaryRuth’s 1 fl oz bottle works out to roughly 29 single-mL servings . Pilly’s label confirms 30 servings per bottle.
- Current price: MaryRuth is $18.95. Pilly is $47.99 at full price, or $40.79 on a subscription.
- Approx. price per 1 mL serving: MaryRuth is about $0.65. Pilly is about $1.60 at full price, or about $1.36 on subscription.
- Format base: MaryRuth is an alcohol-free tincture. Pilly is a glycerin-based liquid sweetened with stevia.
Two Liquid Mushroom Blends, Same 1 mL Basis
Both of these are liquid dropper formulas built around overlapping mushroom species, so the fairest way to compare them is on the same serving size. Both labels use 1 mL as their base serving, which makes a direct side-by-side possible without converting units. We have not purchased, tasted, or tested either product for this comparison – everything above and below comes from what each brand publishes on its own product page and supplement facts panel.
What’s Actually on the MaryRuth Label
MaryRuth’s Organic Mushroom Complex lists six species: Lion’s Mane, Reishi, Agaricus Blazei, Maitake, Shiitake, and Turkey Tail. The supplement facts panel discloses 1,200 mg of “Organic Proprietary Blend Extract” per 1 mL serving, with a stated dry-herb-to-menstruum ratio of 1:16 – the brand notes this works out to roughly 61 mg of dry herb equivalent per 1 mL. Because it’s labeled as a proprietary blend, the amount of any single mushroom inside that 1,200 mg figure is not broken out. The suggested use is up to 1 mL, one to three times daily, for adults and teens 14 and older.
What’s Actually on the Pilly Label
Pilly Labs’ Adaptogen Immunity Drops list the same core mushroom category with some different species: Chaga, Reishi, Maitake, Shiitake, Turkey Tail, and Cordyceps. Worth noting for label-readers: the supplement facts panel splits this into two lines. A “Proprietary Mushroom Immune Complex” of 150 mg covers Chaga, Reishi, Maitake, Shiitake, and Turkey Tail together – those five species aren’t individually broken out, same as MaryRuth’s blend approach. Cordyceps is disclosed separately at 50 mg. Suggested use is one full 1 mL dropper daily.
Species Overlap and What’s Different
Both formulas share four species in common: Reishi, Maitake, Shiitake, and Turkey Tail. MaryRuth adds Lion’s Mane and Agaricus Blazei, which Pilly’s formula doesn’t include. Pilly adds Chaga and Cordyceps, which MaryRuth’s formula doesn’t include. If a specific species is the priority – Lion’s Mane for cognitive-focused routines, or Cordyceps and Chaga for antioxidant and energy-adjacent research – that’s a more useful selection point than the marketing copy on either page.
The Dose-Math Reality: Both Use Blends, Not Full Disclosure
Neither label lets you calculate the exact milligram amount of an individual species per serving. MaryRuth discloses one combined total (1,200 mg) across six species. Pilly discloses one combined total (150 mg) across five species, plus a separate disclosed amount (50 mg) for the sixth. That’s a meaningful practical difference – Pilly’s Cordyceps dose can be evaluated against published research ranges on its own, while none of MaryRuth’s six species or Pilly’s other five can be. For background on reading blend labels generally, see our guide on how to read a mushroom supplement label, and for the math behind evaluating any blend, see our piece on mushroom supplement dose math.
What the Research Says About These Species
Turkey Tail is one of the more studied mushrooms in this category, with published research on polysaccharide and polysaccharopeptide compounds that researchers have examined for a possible role in gut microbiome composition and immune markers. Reishi has a long traditional-use history and has been studied for possible stress-response and immune-modulation activity. Chaga contains polyphenols and melanin compounds that laboratory research has linked to antioxidant activity. Cordyceps has been studied in small randomized trials for markers like natural killer cell activity and exercise tolerance. Maitake and Shiitake both contain beta-glucans that research has examined for immune-modulating properties. None of this research was conducted on either finished product – it’s ingredient-level science, and the doses used in studies frequently differ from what’s in a 1 mL dropper serving. Individual mushroom compounds may support certain aspects of immune function, but neither product is intended to diagnose, treat, cure, or prevent any disease.
Who Should Be Cautious With Either Product
Both brands publish similar caution language. Anyone with a known mushroom allergy should avoid both products. Anyone taking immunosuppressant medication, blood thinners, or other prescription drugs should talk to a physician first, since mushroom compounds could interact with certain medications. Pregnant or nursing individuals, and anyone with a diagnosed medical condition, should consult a healthcare professional before starting either formula. MaryRuth’s label is intended for ages 14 and up; Pilly’s is formulated for adults.
What We Don’t Know
Neither company has published a clinical trial on the finished liquid formula itself – the research each brand cites is on individual mushroom extracts, not on these specific products. Neither label discloses a beta-glucan percentage or extraction ratio for every individual species, so it’s not possible to compare potency claim-for-claim between the two blends. Third-party testing is referenced by Pilly on its product page, but a current certificate of analysis was not available to review for this comparison. Extraction method and standardization details for MaryRuth’s blend beyond the disclosed dry-herb ratio were also not published on the product page at the time of writing.
For a closer look at Pilly’s formula on its own, see our full review of the Adaptogen Immunity Drops label.
Frequently Asked Questions
Is one of these products more potent than the other?
Potency can’t be determined from either label alone, since both use blend totals rather than fully disclosing every individual species amount. MaryRuth’s combined total is higher (1,200 mg vs. Pilly’s 200 mg per 1 mL), but a higher blend total doesn’t necessarily mean a higher amount of any one specific mushroom – the ratio inside each blend isn’t published.
Which one is cheaper per serving?
At current listed prices, MaryRuth works out to roughly $0.65 per 1 mL serving, compared to roughly $1.60 per 1 mL serving for Pilly at full price (about $1.36 on a subscription).
Can I take these together?
Since both products contain overlapping mushroom species, combining full servings of each would meaningfully increase total mushroom extract intake for the day. Anyone considering stacking multiple mushroom supplements should talk to a healthcare professional first, particularly if taking other medications.
Do either of these claim to cure or prevent illness?
No. Both brands include FDA disclaimer language stating their products are not intended to diagnose, treat, cure, or prevent disease. Any immune-support language on either label refers to general wellness support, not a medical claim.
Why does this page disclose that TopShelf Mushrooms and Pilly Labs share ownership?
Clear disclosure of a material connection between a publisher and a product it promotes is a standard practice in consumer protection guidance, including from the FTC’s endorsement guidance. We disclose it here and in every Pilly-related comparison so readers can weigh our coverage accordingly.
These statements have not been evaluated by the FDA. This content is for educational purposes only and is not medical advice. Ask a qualified healthcare professional about supplements, medications, pregnancy, or health conditions.
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